Nav1.7 – HEK 293 Cell line
Catalog #: 60507

Background
Nav1.7 is a voltage-gated sodium ion channel that in humans is encoded by the SCN9A gene. It
is usually expressed at high levels in two types of neurons, the nociceptive neurons at dorsal
root ganglion and trigeminal ganglion, and sympathetic ganglion neurons, which are part of the
autonomic (involuntary) nervous system.

Description
Nav1.7 (Genbank # Q15858) is present at the endings of pain-sensing nerves, the nociceptors,
close to region where the impulse is initiated.The Nav1.7 channel produces a rapidly activating
and inactivating current which is sensitive to level of tetrodotoxin. Knockout mice that lack
Nav1.7 in nociceptors showed reduced response to inflammatory pain [1].

Sequence
A synthetic codon-optimized DNA sequence encoding human NaV1.7 protein [2] with C-terminal
Streptavidin-Binding Peptide (SBP) [3] tag is stably integrated in 293HEK-Trex cells.

Application
• Drug compound screening
• Functional assays
• Efficient antigen for mouse immunization

References:
1. Catterall, W.A. Cell and Developmental Biology 16: 521–555 (2000).
2. Choi, J.S., et al. Neurology 67:1563-1567 (2006).
3. Li, Y., el al. Protein Science 20 (1): 140–149 (2011).

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